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  • Title: Differentiation-associated cellular complex formation of murine thymocytes with thymic stromal cells.
    Author: Hiai H, Sato C, Buma YO, Nishizuka Y.
    Journal: Cancer Res; 1984 Dec; 44(12 Pt 1):5771-5. PubMed ID: 6498838.
    Abstract:
    Properties of normal murine thymocytes forming in vitro cellular complexes with thymic epithelial-like stromal cells in the form of pseudoemperipolesis were studied. The complex-forming cells were low-buoyant-density blasts primarily localized to the subcapsular zone. After transition into small cortical lymphocytes, their capacity for complex formation was lost. The complex-forming cells were relatively resistant to cortisone acetate and low-dose (170 rads) whole-body X-irradiation. Their number increased sharply in the early stage of thymic regeneration, corresponding to an increase in the percentage of large thymic lymphocytes 4 to 5 days after cortisone treatment or X-irradiation. However, after the thymus was repopulated with small lymphocytes, the percentage of complex-forming lymphocytes decreased rapidly to the normal level. A possible relationship between a step in thymic leukemogenesis and intrathymic T-cell differentiation is discussed.
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