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  • Title: Plasma lipid peroxides and alpha-tocopherol in critically ill patients.
    Author: Takeda K, Shimada Y, Amano M, Sakai T, Okada T, Yoshiya I.
    Journal: Crit Care Med; 1984 Nov; 12(11):957-9. PubMed ID: 6499481.
    Abstract:
    Plasma lipid peroxide measured as thiobarbituric acid reactive substances (TBARS) and alpha-tocopherol levels in 24 critically ill patients were compared with those of control subjects. The mean plasma alpha-tocopherol level was significantly lower and the mean TBARS level was significantly higher in critically ill patients. Eight ICU patients developed disseminated intravascular coagulation (DIC); the mean TBARS level during DIC was significantly above the mean pre-DIC level. These results indicate that lipid peroxidation may contribute to the development of DIC in critically ill patients.
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