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  • Title: [Comparative evaluation of the lymphocyte blast-transformation reaction induced by various mitogens in the polychemotherapy of patients with breast cancer].
    Author: Gnatyshak AI, Sabala PI.
    Journal: Eksp Onkol; 1984; 6(1):61-3. PubMed ID: 6499735.
    Abstract:
    The immunity system condition was studied in 118 patients with breast cancer of stage III who received combination chemotherapy: 91 patients--according to the Cooper scheme and 27 patients--according to CMF scheme. The reaction of lymphocyte blast transformation (LBT) was determined by three mitogens: phytohemagglutinin (PHA "O"), PHA "D" and lipopolysaccharide (LPS). The levels of Ig A, G, M were also determined. A decrease in immunological indices of different degree was observed in all patients. LBT was proved to have a high response to phytohemagglutinin "O" and it is recommended for immunological investigations. No significant changes in the immunological state of LPS were revealed.
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