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  • Title: Tetracyclines inhibit parathyroid hormone-induced bone resorption in organ culture.
    Author: Gomes BC, Golub LM, Ramamurthy NS.
    Journal: Experientia; 1984 Nov 15; 40(11):1273-5. PubMed ID: 6500016.
    Abstract:
    Several tetracyclines (minocycline, doxycycline, tetracycline), in levels approximating physiologic concentrations, were found to inhibit parathyroid hormone-induced bone resorption in organ culture; the specificity of this effect was demonstrated by comparison with other (non-tetracycline) types of antibiotics. The ability of tetracyclines to inhibit bone resorption is consistent with the recent proposal by Golub et al. that these antibiotics can inhibit mammalian collagenolytic enzymes by a mechanism unrelated to the drug's antibacterial efficacy, a property which could be therapeutically useful in diseases characterized by excessive collagen breakdown.
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