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  • Title: [Effect of clofelin and apressin on blood circulation and metabolic indices of the brain].
    Author: Sankina ZhV, Gaevyĭ MD.
    Journal: Farmakol Toksikol; 1984; 47(5):32-6. PubMed ID: 6500032.
    Abstract:
    Experiments on cats were made to study the effects of clopheline (5-6 and 10 micrograms/kg) and apressin (1 mg/kg) on the time-course of changes in the cerebral circulation, total arterial and venous pressures, oxygen and glucose concentrations, pH in the arterial and venous blood. It was discovered that clopheline and apressin appreciably reduce the total blood pressure and minimize the volumetric velocity of the cerebral circulation. Brain oxygen and glucose consumption was found to be reduced under the effect of these drugs.
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