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  • Title: [Use of antioxidants for preventing the hepatotoxic effect of acrylonitrile].
    Author: Ivanov VV, Klimatskaia LG.
    Journal: Farmakol Toksikol; 1984; 47(5):96-100. PubMed ID: 6500043.
    Abstract:
    The authors examined the possibility of using antiooxidants in the chemoprophylaxis of poisonings with alkylating chemical compounds. It was demonstrated that vitamin E, ionol and low-molecular thiols (cystein, glutatione and unithiol) prevent the increased permeability of plasma membranes and impairment of the protein-synthesizing function of the endoplasmic reticulum of hepatoytes in acute and chronic acrylonitrile poisoning.
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