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  • Title: Effects of long-term ticlopidine treatment on platelet function and its tolerability in cerebrovascular disease.
    Author: Carrieri P, Orefice G, Fioretti A, Indaco A, Carfagna S.
    Journal: J Int Med Res; 1984; 12(5):286-91. PubMed ID: 6500168.
    Abstract:
    A trial was performed on thirty-two patients with cerebrovascular disease (transient ischaemic attack and stroke) to assess the effect of ticlopidine, a new inhibitor of platelet aggregation, on some platelet functions and coagulation, and its safety in long-term use (6 months). The results show that ticlopidine was highly effective in inhibiting ADP-induced platelet aggregation, platelet adhesiveness and circulating platelet aggregates, but it had no effect on fibrinogen levels. No serious side-effects were observed. Ticlopidine may therefore prove to be a useful antiplatelet drug in the management of patients with cerebrovascular disease.
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