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  • Title: High-performance liquid chromatography systems for the separation of local anaesthetic drugs with applicability to the analysis of illicit cocaine samples.
    Author: Gill R, Abbott RW, Moffat AC.
    Journal: J Chromatogr; 1984 Sep 28; 301(1):155-63. PubMed ID: 6501485.
    Abstract:
    Two high-performance liquid chromatography (HPLC) systems are presented which are suitable for the separation of local anaesthetic drugs. An octadecyl-silica column is used with aqueous methanolic eluents (15 and 50% respectively) containing n-hexylamine-orthophosphoric acid buffers and data for 36 compounds are given. The HPLC systems have application for the identification of unknown drugs in this class while the first eluent (15% methanol, pH 2.5) is particularly useful for the examination of illicit cocaine samples because it gives good separation of common adulterants and impurities.
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