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  • Title: Novel pyrimidine and 1,3,5-triazine hypolipidemic agents.
    Author: d'Atri G, Gomarasca P, Resnati G, Tronconi G, Scolastico C, Sirtori CR.
    Journal: J Med Chem; 1984 Dec; 27(12):1621-9. PubMed ID: 6502593.
    Abstract:
    New compounds were synthesized by changing the substituents of a trisubstituted pyrimidine, i.e., [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio] acetic acid, a potent hypolipidemic agent, impaired, however, by a marked hepatomegaly-inducing effect. The structural variations led to the subsidence (14b, i.e., 4-chloro-2-(dimethylamino)-6-[(2,3-dimethylphenyl)amino]pyrimidine) or to the reduction (18b, [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]amino] acetic acid) of said untoward effect but still maintained the hypolipidemic effect that, although markedly decreased, still proves significant for serum cholesterol and triglycerides (18b) or for serum triglycerides only (14b).
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