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  • Title: [Characteristics of the proliferative activity of the aggregates forming during recombination of the epithelium and mesenchyma of embryonic lungs from intact and carcinogen-treated mice].
    Author: Kolesnichenko TS, Antoshina EE, Medvinskiĭ AL.
    Journal: Ontogenez; 1984; 15(5):522-8. PubMed ID: 6504500.
    Abstract:
    Methods of separation of the mouse embryonic lung mesenchyme (M) and epithelium (E) and obtaining homolinear and heterolinear organotypic aggregates of E and M from the intact and urethane-treated (transplacentally) A and C57BL mouse embryos. In the aggregates formed by E and M from the experimental A embryos, the index of labelled nuclei (3H-thymidine incorporation) in both the tissue components was several times that in the aggregates of E and M from the intact embryos. M from the experimental embryos aggregated with E from the intact embryos increased the proliferative activity of the latter 4 to 11 times, whereas M of the intact embryos aggregated with E of the experimental embryos decreased its proliferative activity to the normal level. A suggestion is put forward that the embryonic lung mesenchyme plays an important role in the realization of transplacental carcinogenic influences and in the development of lung epithelial tumours.
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