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  • Title: Evidence for the hormonal regulation of the multimolecular forms of serum alkaline phosphatase.
    Author: Brocklehurst D, Wilde CE.
    Journal: Prog Clin Biol Res; 1984; 166():277-88. PubMed ID: 6504933.
    Abstract:
    The relationship between serum alkaline phosphatase (AP) activity and hormonal status was investigated in normally menstruating women. oral contraceptive (OC) users, and in women attending an infertility clinic and in early and late pregnancy. Reliable measurement of small differences in serum AP is now possible as a result of improvements in faractionation, sample handling techniques, and precision in AP assays. The centrifugal analyzer method used in these studies gives a within-batch precision of 0.4% compared to the 4-5% precision obtained with eaarlier methods. The maximun divergence in levels of circulating AP was noted in the 30-35year age group, which corresponds to the peak 24 hour urinary excretion of estrogen between days 10-20 of the menstrual cycle. Only limited changes of liver-bone AP were demonstrated in the luteal and menstrual phases of the normal cycle, although a marked increase in intestinal AP was noted during menses. Serum AP increased during menses in OC users. The removal of suppression on AP produces an increase during days 21-27. Among women attending an infertility clinic, those with lower hormone levels had a wider range of serum AP activity and a greater incidence of intestinal AP. The finding that ptients with progesterone levels under 7.5 nmol/1 with normal levels of estradiol has raised serum AP levels suggests that progesterone may modulate the estrogenic effect on serum AP levels. Finally, an inverse relationship was found between intestinal AP and levels of estradiol and progesterone in different phases of the menstrual cycle and in early and late pregnancy. These results suggest that small or large increases in estrogen increase pinocytosis, which reduces the level of the circulating glycoprotein AP by cell binding.
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