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  • Title: Hyperpolarization produced by methohexitone in the chick biventer cervicis skeletal muscle.
    Author: Wali FA.
    Journal: Pharmacol Res Commun; 1984 Sep; 16(9):945-56. PubMed ID: 6504974.
    Abstract:
    The effect of methohexitone on endplate potential and on depolarizations produced by acetylcholine (ACh) and tetraethylammonium (TEA) was studied in the isolated chick biventer cervicis skeletal muscle using a sucrose-gap recording technique. Methohexitone (5.5-180 uM) produced concentration-dependent hyperpolarization in the chick skeletal muscle without producing an initial contracture. Methohexitone had a differential effect on the depolarizations produced by ACh (5.5 uM- 11 mM) and TEA (0.95- 48 mM); it greatly reduced the ACh whereas it increased the TEA-induced responses. It was suggested that methohexitone had a dual postjunctional action, but a presynaptic effect was not ruled out.
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