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  • Title: [The effect of x-rays on the level, composition and para-nitroanisole-o-demethylase activity of cytochrome P-450 in the liver microsomes of rats].
    Author: Deev LI, Akhalaia MIa, Vasilenko OV, Platonov AG, Topchishvili GI.
    Journal: Radiobiologiia; 1984; 24(5):612-5. PubMed ID: 6505149.
    Abstract:
    A study was made of the effect of X-radiation of different doses on the content of P-450 cytochrome in a microsomal fraction of rat liver. When the haemoprotein level markedly decreased an increase in Km and a decrease in Vmax were noted in the reaction of O-demethylation of para-nitroanisole by microsomes of the irradiated rat liver. It is suggested that one of the cause of the effect observed is the postirradiation change in the composition of cytochrome P-450 pool resulting from a selective decrease in the level of the radiosensitive forms of haemoprotein.
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