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  • Title: [Repaired and unrepaired DNA damage induced by x-irradiation of nonproliferating rat hepatocytes].
    Author: Smirnova IS, Noskin LA, Suslov AV.
    Journal: Radiobiologiia; 1984; 24(5):620-3. PubMed ID: 6505151.
    Abstract:
    An effective system of repair of double-strand DNA breaks was found in the stock culture of rat hepatocytes by the method of elastoviscosimetry. The inhibitors of DNA resynthesis, hydroxyurea and arabinosyl cytosine, which transformed single-strand breaks into double-strand ones were used to estimate the level of spontaneous affection of the hepatocyte genome. With a reference to this level the authors have demonstrated that after a dose of 2 Gy and 6-24-hour repair, the additional number of lesions was registered. These lesions were shown to be incised by nucleases similar to those involved into the conventional repair process.
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