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  • Title: Activated expression of the N-myc gene in human neuroblastomas and related tumors.
    Author: Kohl NE, Gee CE, Alt FW.
    Journal: Science; 1984 Dec 14; 226(4680):1335-7. PubMed ID: 6505694.
    Abstract:
    In neuroblastoma lines in which the N-myc gene is present as a single copy, the expression of N-myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors. The increase of expression in neuroblastomas with amplified N-myc genes is the result of (i) an increase in the absolute amount of expression of each N-myc gene and (ii) an increase in the copy number of the N-myc gene. A second gene--which is amplified in many of the same lines as N-myc--is expressed to about the same degree in most human cell lines and primary tumors regardless of origin (when normalized to gene copy number). Thus, a change in the regulation of N-myc expression in neuroblastomas and certain other tumors results in greatly increased expression of each N-myc gene copy.
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