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  • Title: Effects of betacarbolines on the automaticity of the guinea pig sinus node.
    Author: Carpentier RG.
    Journal: Subst Alcohol Actions Misuse; 1984; 5(3):141-8. PubMed ID: 6505936.
    Abstract:
    The effects of betacarbolines on guinea-pig isolated sinus nodes superfused with Tyrode's solution at 35 degrees C were analyzed. All analogs depressed the automaticity. The phase 4 of transitional fibers was depressed, in the absence of any change in maximum diastolic potential. The threshold for harmaline action was 10(-7)M. Dehydrogeneration of harmaline into harmine increased the potency. Removal of the methoxy group (harmane) did not modify the potency but accelerated the recovery. Substitution of the methoxy group by a hydroxy group (harmalol and harmol) reduced markedly the potency of harmaline and harmine, respectively.
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