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  • Title: [Trans-cerebral electrophoresis of L-DOPA in the complex treatment of parkinsonism].
    Author: Neĭmark EZ, Evtushenko SK, Dukhovnaia MA.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1984; 84(9):1334-8. PubMed ID: 6506979.
    Abstract:
    Based on the established electrophoretic mobility of L-DOPA and on pathogenetic assumptions, the authors carried out multiple modality treatment employing transcerebral L-DOPA electrophoresis in 48 patients with postencephalic and atherosclerotic parkinsonism. The majority of patients (43 subjects) showed an improvement of various degrees, particularly when rigidity and oligo- and bradykinesia were predominant in the clinical picture of the disease. Of the 48 patients treated, 29 received L-DOPA per os and 19 patients were given low drug doses. The therapeutic effect persisted from 2 weeks to 2-3 months.
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