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  • Title: A fresh look at iontophoresis.
    Author: Hughes L, Maurice DM.
    Journal: Arch Ophthalmol; 1984 Dec; 102(12):1825-9. PubMed ID: 6508622.
    Abstract:
    The rate of penetration of fluorescein and gentamicin ions into the anterior chamber of the rabbit was increased more than 100-fold by the passage of 1 mamp; the amount of drug that penetrates is better controlled by iontophoresis than by instillation. The potential value, the safety and the limitations of this procedure are discussed, and a theoretical basis for the increase is provided. Practical methods of using iontophoresis in the clinic are described. A 30-s application should result in a therapeutic level of the antibiotic in the anterior segment over a 12-hour period in eyes with an intact epithelium.
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