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  • Title: Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin.
    Author: Nishino H, Fujiki H, Suganuma M, Horiuchi T, Iwashima A, Sugimura T.
    Journal: Biochem Biophys Res Commun; 1984 Nov 14; 124(3):726-30. PubMed ID: 6508780.
    Abstract:
    A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 mumoles of W-7, reaching a maximum of 86% after 5 min. Reduction in specific binding of 12-O-tetra-decanoylphorbol-13-acetate can explain the antitumor promoting activity of W-7 in mouse skin.
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