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  • Title: Cell-cycle distributions and radiation responses of Chinese hamster cells cultured continuously under hypoxic conditions.
    Author: Tokita N, Carpenter SG, Raju MR.
    Journal: Br J Radiol; 1984 Dec; 57(684):1137-43. PubMed ID: 6509292.
    Abstract:
    Cell-cycle distributions were measured by flow cytometry for Chinese hamster (CHO) cells cultured continuously under hypoxic conditions. DNA histograms showed an accumulation of cells in the early S phase followed by a traverse delay through the S phase, and a G2 block. During hypoxic culturing, cell viability decreased rapidly to less than 0.1% at 120 h. Radiation responses for cells cultured under these conditions showed an extreme radioresistance at 72 h. Results suggest that hypoxia induces a condition similar to cell synchrony which itself changes the radioresistance of hypoxic cells.
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