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  • Title: Relation between fetal arterial PO2 and oxytocin-induced uterine contractions in pregnant sheep.
    Author: Lye SJ, Wlodek ME, Challis JR.
    Journal: Can J Physiol Pharmacol; 1984 Oct; 62(10):1337-40. PubMed ID: 6509382.
    Abstract:
    The relation between oxytocin-induced type A uterine contractions and fetal arterial PO2, measured continuously with an intravascular oxygen electrode, was studied in nine chronically catheterized sheep during late pregnancy. Oxytocin provoked dose-related increases in intrauterine pressure (IUP) and decreases in fetal PaO2. There was a significant positive relationship between changes in IUP and the maximum decrease in fetal PaO2 (average r = 0.696, df = 92; P less than 0.001). We conclude that changes in uterine activity contribute to transient fetal hypoxemia, and that administration of exogenous oxytocin provides an experimental paradigm to examine the consequences of this relationship.
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