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  • Title: Cerebral high energy phosphates after hypoxic-hypotension: effect of verapamil and nifedipine.
    Author: Proctor HJ, Palladino GW, Fillipo D, Sanders R.
    Journal: Circ Shock; 1984; 14(2):107-12. PubMed ID: 6509723.
    Abstract:
    Rats were subjected to 30 minutes of hypoxic-hypotension and then allocated to one of four treatment groups. Group I was resuscitated by restoration of FIO2 = 30% and reinfusion of shed blood plus an equal volume of additional saline. Group II received in addition nifedipine, 10 micrograms/kg, and groups III and IV received in addition either verapamil, 0.2 mg/kg or 1 mg/kg, respectively. Significantly (P less than 0.01) higher concentrations of creatine phosphate and ATP were present in the brain after nifedipine and after 1 mg/kg verapamil treatment.
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