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  • Title: Branched chain alpha-keto acid dehydrogenase in tissues from rainbow trout (Salmo gairdnerii).
    Author: Ottesen I, Klungsøyr L.
    Journal: Comp Biochem Physiol B; 1984; 79(3):489-91. PubMed ID: 6509938.
    Abstract:
    Mitochondria isolated from skeletal red muscle of rainbow trout (Salmo gairdnerii) have remarkably high activity of branched chain alpha-keto acid dehydrogenase as measured with alpha-keto isocaproic acid as substrate. The activity of the dehydrogenase increases several-fold after preincubation of the mitochondria with an uncouple and oligomycin. The accumulation of the first product, isovaleryl-CoA is strongly stimulated by high concentrations of CoASH. In the crude mitochondrial lysates we have used, an unknown compound accumulates with time, during incubation with alpha-keto isocaproic acid, CoASH and NAD. The compound, probably a CoA derivative, is more hydrophobic than isovaleryl-CoA.
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