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  • Title: [Analysis of uterine sarcoma induced in mice in terms of the two-staged development of tumors].
    Author: Turusov VS, Linnik AB, Morozova OV, Parfenov IuD.
    Journal: Eksp Onkol; 1984; 6(2):20-3. PubMed ID: 6510329.
    Abstract:
    The results of combined treatment of CBA female mice with 1,2-dimethylhydrazine (DMH) and estradiol dipropionate (EP) are discussed in terms of a two-stage carcinogenesis hypothesis. 20% of mice treated with DMH alone developed uterine sarcomas. EP given after the cessation of DMH-treatment increased sarcoma incidence as high as 60.6% (5 micrograms EP) or 66.7% (10 micrograms EP) and significantly decreased the time of the first tumour appearance. From the standpoint of the two-stage carcinogenesis it is considered possible for EP to influence the tumour-initiating stage.
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