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  • Title: [Alkyl-6-benzoxazolinones. A chemical and pharmacodynamic study].
    Author: Caignard DH, Vaccher MP, Bonte JP, Lesieur D, Cazin M, Brunet C, Luyckx M.
    Journal: Farmaco Sci; 1984 Oct; 39(10):830-6. PubMed ID: 6510517.
    Abstract:
    A series of 6-alkylbenzoxazolinones was synthesized by reduction of corresponding acyl derivatives. Two reduction processes were used, Clemmensen reduction and triethylsilane-trifluoroacetic acid reduction, but only the latter represents a general procedure for synthesis of alkyl derivatives. Pharmacological study shows that reduction of the carbonyl group is accompanied by a decrease of analgesic activity with appearance of a psycholeptic profile.
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