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  • Title: Bimodal effects of MVE-2 on cytotoxic activity of natural killer cell and macrophage tumoricidal activities.
    Author: Piccoli M, Saito T, Chirigos MA.
    Journal: Int J Immunopharmacol; 1984; 6(6):569-76. PubMed ID: 6511143.
    Abstract:
    Maleic anhydride divinyl ether of molecular weight 15,500 (MVE-2) increased tumoricidal activity of NK cells and M phi in a dose-dependent manner with the peak response of both effector cells occurring 3 days following treatment. Both effector cell responses were sustained for over 7 days following one injection. However, repeated injections with MVE-2 led to a hyporesponsiveness of NK cells whereas M phi activity remained high. Poly ICLC, but not C. parvum, reconstituted NK cell activity in mice hyporesponsive to MVE-2. Significant antitumor response was achieved when tumor cells were inoculated at the peak time of effector cell response, indicating the in vivo role of NK and/or M phi in exerting a tumoricidal effect.
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