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  • Title: Utilization of temperature-sensitive mutants of Mycoplasma gallisepticum to prevent air sac infections.
    Author: Lam KM, Lin W, Yamamoto R, Ghazikhanian GY.
    Journal: Isr J Med Sci; 1984 Oct; 20(10):992-4. PubMed ID: 6511327.
    Abstract:
    Three stable temperature-sensitive (ts) mutants were obtained by treating the S6 strain of Mycoplasma gallisepticum with 50 micrograms/ml of nitrosoguanidine. These mutants were morphologically and serologically indistinguishable from the parent S6 strain. Mutants ts 37 and ts 102 were apathogenic, and ts 100 was moderately pathogenic to chickens when inoculated directly into the air sac. To turkeys, ts 37 remained apathogenic, ts 102 was slightly pathogenic, and ts 100 was highly pathogenic, Intranasal immunization of newly hatched chickens with any of the mutants resulted in antibody production, but only ts 100 and ts 102 protected chickens against experimental M. gallisepticum infections 3 weeks later. Vaccination of 2-day-old turkeys with ts resulted in erratic antibody response; however, 5 weeks after immunization, turkeys were able to resist challenge with the virulent S6 strain at a highly significant level.
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