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  • Title: Sister-chromatid exchanges in lymphocytes of smokers in an experimental study.
    Author: Husgafvel-Pursiainen K, Sorsa M, Järventaus H, Norppa H.
    Journal: Mutat Res; 1984; 138(2-3):197-203. PubMed ID: 6513975.
    Abstract:
    The frequency of sister-chromatid exchanges (SCEs) was studied in peripheral blood lymphocytes of 26 young male smokers and 10 non-smokers who had recently entered military service. The levels of SCEs were examined in 4 consecutive blood samples taken after short experimental periods of smoking only low-tar (LT) or medium-tar (MT) cigarettes. The incidence of SCEs was significantly higher in the the group of smokers than in the group of non-smokers. The SCE levels of the smokers were found to be associated with the personal smoking history; the observed increase in the SCE frequency correlated with the years of smoking measured as cumulative pack years. The difference in type of cigarette did not influence the SCE frequencies.
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