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  • Title: A new method for sister-chromatid exchange studies in vivo, a single injection of BrdU in melted agar.
    Author: Qin S, Huang CC.
    Journal: Mutat Res; 1984; 141(3-4):189-93. PubMed ID: 6513979.
    Abstract:
    Details are given for a new, rapid, and simple method of BrdU administration for SCE studies in vivo. BrdU was dissolved in melted agar and administered to mice as a single subcutaneous injection. Clear and reproducible sister chromatid differential staining of bone marrow cells was obtained. Melted agar, when injected into mice, solidified quickly and formed a clump which provided a sustained release of BrdU. HPLC analyses showed that a considerable serum level of BrdU was maintained for at least 10 h in a mouse injected with 25 mg of BrdU in agar.
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