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  • Title: Saturable uptake of [3H]-tryptamine in rabbit platelets is inhibited by 5-hydroxytryptamine uptake blockers.
    Author: Segonzac A, Tateishi T, Langer SZ.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1984 Nov; 328(1):33-7. PubMed ID: 6514017.
    Abstract:
    [3H]-tryptamine is taken up by rabbit platelets through an active and saturable process which is temperature sensitive, sodium-dependent and inhibited by imipramine and non-tricyclic 5-hydroxytryptamine (5-HT) uptake blockers. There is an excellent correlation between the Ki for the inhibition of [3H]-tryptamine and [3H]-5-HT uptake in rabbit platelets for a series of 5-HT uptake blockers. These results indicate that [3H]-tryptamine is actively transported through the membrane of blood platelets by the same carrier that transports 5-HT.
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