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  • Title: Late preventive effects on carbon tetrachloride-induced necrosis of the inhibitor of proteases 1-1-chloro-3-tosyl amido-7-amino-2-heptanone (TLCK).
    Author: de Ferreyra EC, de Fenos OM, Castro JA.
    Journal: Res Commun Chem Pathol Pharmacol; 1984 Nov; 46(2):289-92. PubMed ID: 6515120.
    Abstract:
    The administration to rats of the inhibitor of proteases 1-1-chloro-3-tosyl-amido-7-amino-2-heptanone (TLCK) 6 or 10 h after carbon tetrachloride (CCl4), significantly prevented liver necrosis induced by this hepatotoxin at 24 h. The present and previous results from our laboratory suggest that degradative processes mediated by proteases and esterases might play a role in late stages of CCl4-induced liver cell injury.
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