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  • Title: [Pirbuterol and salbutamol aerosol for exercise-induced bronchoconstriction].
    Author: Aebischer JC, Benoit RC, Scherrer M.
    Journal: Schweiz Med Wochenschr; 1984 Nov 17; 114(46):1660-4. PubMed ID: 6515368.
    Abstract:
    Exercise-induced bronchoconstriction was produced in 12 asthmatic patients after a 6 minutes run on a 10% steep treadmill ergometer. FEV1 decreased by 12-73% (average 27%) of the control value measured before the run. The rather severe exercise-induced bronchoconstriction remained constant for 10-20 minutes after the run. 21 minutes after the run two puffs of a bronchodilator (salbutamol 0.2 mg or pirbuterol 0.4 mg) were inhaled in an open randomized cross-over fashion at intervals of 1 to 3 days. Following both bronchodilators FEV1 returned to the control value within 5 minutes. There was no significant difference between the bronchodilating effect of salbutamol versus pirbuterol. Furthermore, no significant differences were observed in pulse rates after inhalation of the two selective beta-2-stimulators. In our trial both pirbuterol and salbutamol seemed to be well tolerated; side effects were not observed for either drug.
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