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  • Title: [Cytoplasmatic receptors of steroid hormones in malignant epithelial ovarian tumors].
    Author: Makhova EE, Gershteĭn ES, Smirnova KD, Murav'eva NI, Kuz'mina ZV.
    Journal: Vopr Onkol; 1984; 30(12):36-40. PubMed ID: 6516272.
    Abstract:
    The levels of estrogen, progesterone, androgen and glucocorticoid receptors were assayed in 70 malignant epithelial tumors of human ovaries. The percentage of progesterone, androgen and glucocorticoid receptor-positive tumors was significantly higher in reproductive patients than in menopausal ones. Well-differentiated serous cystadenocarcinomas showed a higher level of progesterone receptors than those characterized by poor differentiation of cells. It was found that steroid hormone receptor profile of primary tumor may be determined in its metastases into the greater omentum whenever tumor cannot be removed. In cases of preoperative chemotherapy, the percentage of receptor-positive ovarian tumors was lower.
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