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  • Title: [Virus-like particles in cultures of rheumatoid synovial cells].
    Author: Neumark T, Takács J.
    Journal: Vopr Virusol; 1984; 29(5):575-82. PubMed ID: 6516327.
    Abstract:
    Cultures of synovial cells from 8 patients with classical or determined rheumatoid arthritis and 3 patients with non-rheumatoid arthrosis were examined electron microscopically. Cells of the monolayer formed upon prolonged incubation of tissue pieces had the conventional ultrastructure of synovial cells. In 2 out of 8 cultures of rheumatoid synovial cells after 14 days of incubation, budding virus-like particles with the external diameter of 100-120 nm were observed. Morphologically these particles were very similar to retroviruses. Isolated particles had a buoyant density in sucrose of 1.15-1.17 g/cm3.
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