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  • Title: Metabolism of tenoxicam in rats.
    Author: Ichihara S, Tsuyuki Y, Tomisawa H, Fukazawa H, Nakayama N, Tateishi M, Joly R.
    Journal: Xenobiotica; 1984 Sep; 14(9):727-39. PubMed ID: 6516446.
    Abstract:
    The structures of six metabolites of tenoxicam in rats (2 mg/kg, orally), elucidated by physicochemical analyses or the reverse-isotope dilution method, were 5'-hydroxytenoxicam (5% dose), 3-(methylsulphamoyl)-2-thiophenecarboxylic acid (9% dose), and the C-7 or C-8 O-glucuronide of tenoxicam (30% dose). The mechanism of formation of N-methylthiophenesulphimide, a possible precursor of 3-(methylsulphamoyl)-2-thiophenecarboxylic acid from tenoxicam, is discussed.
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