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  • Title: Transport of branched-chain amino acids in brain slices of developing and adult rats.
    Author: Pajari M.
    Journal: Acta Physiol Scand; 1984 Nov; 122(3):415-20. PubMed ID: 6516888.
    Abstract:
    The accumulation of labelled leucine, isoleucine and valine by cerebral slices of developing and adult rats was studied. The accumulation increased with age by 15-25%. It was strongly (from 52 to 86%) inhibited by a 100-fold excess of phenylalanine, tryptophan and another branched-chain amino acid, but moderately activated by GABA and glutamate. The inhibitions evoked by leucine and isoleucine were slightly stronger in young than in adult rats. The corresponding 2-oxoacid analogs of leucine, isoleucine and valine were also inhibitory but less effective. The 30-min accumulation of 3H-labelled branched-chain amino acids was ostensibly higher than the increase in their total concentrations in incubated slices, which apparently bespeaks lively homoexchange of endogenous intracellular and labelled extracellular amino acids.
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