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  • Title: Relapsing polychondritis with segmental necrotizing glomerulonephritis.
    Author: Botey A, Navasa M, del Olmo A, Montoliu J, Ferrer O, Cardesa A, Darnell A, Revert L.
    Journal: Am J Nephrol; 1984; 4(6):375-8. PubMed ID: 6517117.
    Abstract:
    Glomerulonephritis is a very unusual feature of relapsing polychondritis. A 16-year-old woman presented with microscopic hematuria and severe renal insufficiency during the course of relapsing polychondritis. A renal biopsy specimen disclosed focal segmental proliferative glomerulonephritis with necrotizing lesions and crescent formation. Immunofluorescent studies suggested immune complex mediated glomerular injury. The renal involvement appeared during high-dose steroid therapy. Subsequently, she was treated by adding plasmapheresis and cyclophosphamide during 6 weeks, with sustained improvement. A regimen of plasmapheresis and immunosuppression warrants consideration for use in cases of relapsing polychondritis with glomerulonephritis.
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