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  • Title: Thermal stability of the Z-conformation of the tetranucleoside triphosphate (m5dC-dG)2.
    Author: Genest D, Hartmann B, Thuong NT, Ptak M, Leng M.
    Journal: Biochem Biophys Res Commun; 1984 Dec 14; 125(2):803-11. PubMed ID: 6517926.
    Abstract:
    The tetranucleoside triphosphate d(m5C-G)2 has been studied in solution by circular dichroism and 31P nuclear magnetic resonance as a function of temperature, in presence of 3 M NaClO4. It is shown that in such high ionic strength d(m5C-G)2 may adopt a Z-like conformation for temperatures lower than 5 degrees C. At these temperatures, another conformation, in slow equilibrium with the Z-like one, is also detected. Increasing the temperature leads to a transition from the Z-like conformation to intermediate forms before melting. It is demonstrated that these intermediates are not the B form.
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