These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Platelet aggregability, disaggregability and serotonin uptake in migraine.
    Author: Kruglak L, Nathan I, Korczyn AD, Zolotov Z, Berginer V, Dvilansky A.
    Journal: Cephalalgia; 1984 Dec; 4(4):221-5. PubMed ID: 6518502.
    Abstract:
    Several disturbances in platelet function have been reported in migraineurs including serotonin (5-HT) metabolism and abnormal aggregability of platelets. The present work compared platelets taken from migraineurs during attacks and at headache-free periods with those of controls. The results demonstrated a tendency to increased aggregability during attacks compared to headache-free periods, and lower still in controls. Kinetic analysis of 5-HT uptake revealed normal Km, increased Vmax values and lower imipramine inhibition in migraineurs (both during headache and at headache-free periods). However, although the differences were significant statistically, they were small, and their clinical relevance remains to be proven.
    [Abstract] [Full Text] [Related] [New Search]