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  • Title: [Effect of chronic stimulation of the negative and positive emotionogenic centers of the hypothalamus on development of cardiac arrhythmias].
    Author: Ul'ianinskiĭ LS, Balashov AN, Gritsak AV, Kashtanov SI.
    Journal: Biull Eksp Biol Med; 1976; 82(11):1288-91. PubMed ID: 65188.
    Abstract:
    Chronic experiments were conducted on 46 rabbits; a study was made of the changes in cardiac activity arising in prolonged (up to 1--2 weeks) electric stimulation of the ventro-median nuclei of the hypothalamus. Disturbances of the cardiac rhythm in the form of tachycardia, atrial flutter and fibrillation, ventricular extrasystole and paroxysmal ventricular tachysystole occurred mostly during the first days of stimulation and ceased after inderal infusion. Functional "weakness" of the cardiac pacemakers was revealed in the animals subjected to 1--2-week stimulation of the ventromedian nuclei. This was indicated by the post-stimulation suppression of the pacemaker automaticity and the appearance of Liciani's periods. Disturbances of the cardiac rhythm originating in stimulation of the ventromedian nuclei ceased in stimulation of the lateral hypothalamic field.
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