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  • Title: New derivatives of pyrrolo and pyrido[2,1-b] quinazoline as antiulcer agents.
    Author: Doria G, Passarotti C, Magrini R, Sala R, Sberze P, Tibolla M, Arcari G, Ceserani R, Castello R.
    Journal: Farmaco Sci; 1984 Nov; 39(11):968-78. PubMed ID: 6519266.
    Abstract:
    A series of 3-benzylidene-1,2,3,9-tetrahydro-9-oxopyrrolo-[2,1-b] quinazolinecarboxylic acids and 6-benzylidene-6,7,8,9-tetrahydro-11-oxo-11H-pyrido[2,1-b] quinazolinecarboxylic acid was synthesized and evaluated for their antiulcer activity by the test of inhibition of restraint ulcers in the rat, and for gastric antisecretory activity using the technique of Shay. Some compounds appear potentially useful for therapeutic application.
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