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  • Title: Absence of naturally acquired tetanus antitoxin in the free-ranging Cayo Santiago rhesus monkeys (Macaca mulatta).
    Author: Kessler MJ, Rawlins RG.
    Journal: J Med Primatol; 1984; 13(6):353-7. PubMed ID: 6520863.
    Abstract:
    Tetanus is enzootic in the free-ranging rhesus monkey colony on Cayo Santiago. The disease accounts for 25% of all mortalities in the population. The high prevalence of tetanus provided a unique opportunity to study the potential roles of geophagia, wounding, and clinical tetanus infections on the development of naturally acquired tetanus antitoxin in rhesus macaques. Eighty-six unvaccinated monkeys, including six that recovered from tetanus, were serosurveyed using a mouse toxin neutralization test. None of the animals had detectable antitoxin titers (less than 0.001 AU/ml), suggesting that natural immunity to tetanus is either rare or nonexistent in the Cayo Santiago colony.
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