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  • Title: A role of elementary interactions between nucleic-acid base and amino-acid side chains in specificity of ribonuclease.
    Author: Takenaka A, Shibata M, Takimoto M, Sasada Y.
    Journal: Nucleic Acids Symp Ser; 1984; (15):113-6. PubMed ID: 6522281.
    Abstract:
    Several X-ray structures of model crystals that contain hydroxyl group and nucleic-acid bases suggest that hydroxyl group interacts preferentially with pyrimidines than with purines through hydrogen bonds. This explains a role of Thr 45 and Ser 123 at the B1 site of RNAase A. The stacking energies of nucleic-acid bases with the protonated imidazolyl group are estimated to be in the order of C greater than A greater than G greater than U from 1H-NMR spectra and CNDO/2 calculations. Such interactions, in addition to hydrogen bondings, would stabilize the binding of substrates at the B2 site.
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