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  • Title: Distribution and metabolism of dermorphin in rats.
    Author: Negri L, Improta G.
    Journal: Pharmacol Res Commun; 1984 Dec; 16(12):1183-91. PubMed ID: 6522442.
    Abstract:
    Dermorphin distribution and metabolism were studied in rats injected with high doses of the peptide and with 125I-dermorphin, using RIA methods, HPLC extraction and -counting. Dermorphin rapidly disappeared from plasma (half-life: 1.3 min). In vivo and in vitro experiments demonstrated that the peptide was destroyed in liver and kidney. The highest percent (11%) of injected dermorphin has been found in the bile collected over 1 hour. HPLC analysis showed that bile contained also breakdown products (di, tri, and tetra N-terminal peptide fragments). Reported data suggested that intact dermorphin can be eliminated more slowly than breakdown products.
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