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  • Title: Denitrosation of diphenylnitrosamine in vivo.
    Author: Appel KE, Rühl CS, Spiegelhalder B, Hildebrandt AG.
    Journal: Toxicol Lett; 1984 Dec; 23(3):353-8. PubMed ID: 6523527.
    Abstract:
    A single dose of diphenylnitrosamine (NDphA) was applied orally or intraperitoneally (i.p.) to rats. The urine was sampled and analysed for nitrite/nitrate by ion chromatography and for diphenylamine (DphA) plus hydroxydiphenylamine by gas chromatography. The major metabolite was nitrate. Nitrite and DphA were found in minor amounts. In a somewhat higher concentration, a monohydroxylated DphA was detected. It is concluded that NDphA is denitrosated to nitric oxide (NO) and DphA in the organism and that NO is then converted into nitrite and nitrate.
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