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  • Title: [Characteristics of hepatocyte proliferation in the regenerating rat liver with hydroxyurea synchronization of the proliferative processes].
    Author: Osipova LA, Zatsarnaia AP, Khranovskaia LN, Bykorez AI.
    Journal: Tsitologiia; 1984 Nov; 26(11):1278-82. PubMed ID: 6523573.
    Abstract:
    5-week old rats underwent a partial hepatectomy (2/3 of the liver was removed). The operated rats were repeatedly injected hydroxyurea, within 9-24 or 12-24 hours following operation. Proliferation of hepatocytes and non-parenchymal cells in the regenerating liver was studied. Five or six injections of hydroxyurea increased the labelling index of hepatocytes up to 62.5% and induced proliferation of bile duct cells significantly.
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