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  • Title: [Role of M- and N-cholinergic systems in the recovery of motor functions after removal of the motor zones of the cerebral cortex in cats].
    Author: Shalkovskaia LN, Losev NA.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1984; 34(6):1066-71. PubMed ID: 6524065.
    Abstract:
    In chronic experiments on cats with unilateral ablations of the motor cortical area, recovery of motor function of the contralateral forelimb was observed in average on the 31-th day after ablation. Stimulation of M-cholinoreactive brain biosystems by galantamine in combination with simultaneous suppression of N-cholinoreactive biosystems by ganglerone, shortened the period of complete compesation up to 10 days. Suppression of M-cholinoreactive systems and simultaneous stimulation of N-cholinoreactive ones by metamisil combined with galantamine prolonged the recovery period up to several months. A conclusion is drawn of an important role of M- and N-cholinergic mechanisms in providing compensatory possibilities of the brain.
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