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  • Title: On the presence of H1-receptors in various sections of guinea-pig heart: a correlation between binding and functional studies.
    Author: Bennardini F, Amerini S, Franconi F, Ledda F, Mantelli L, Matucci R, Mugelli A, Sorbi C.
    Journal: Agents Actions; 1984 Oct; 15(3-4):167-71. PubMed ID: 6524516.
    Abstract:
    The binding of 3H-mepyramine in different sections of guinea-pig heart was examined. 3H-mepyramine binds to a single class of binding sites to guinea-pig ventricular membranes and to right atrial suspension with an apparent dissociation constant (Kd) of 4.35 nM and 14.90 nM respectively. When treated as those obtained from the right atrium, the left atrial suspensions do not seem to bind 3H-mepyramine specifically.
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