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  • Title: Involvement of hysteretic effects in the inhibition of carnitine palmitoyltransferase by malonyl-CoA.
    Author: Cook GA.
    Journal: Biochem J; 1984 Dec 15; 224(3):1015-8. PubMed ID: 6525169.
    Abstract:
    Carnitine palmitoyltransferase in its normal mitochondrial environment behaves as a hysteretic enzyme, exhibiting slow changes in reaction rate after the addition of oleoyl-CoA or malonyl-CoA. Reaction rates become constant after a short time, but the sensitivity of the enzyme from fed rats to the inhibition by malonyl-CoA remains much greater than that of starved rats.
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