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  • Title: [Multiple forms of hypophyseal prolactin. A new glycosylated form of prolactin with increased biological activity].
    Author: Butnev VIu, Pankov IuA.
    Journal: Biokhimiia; 1984 Nov; 49(11):1828-39. PubMed ID: 6525362.
    Abstract:
    Different forms of prolactin obtained from porcine hypophysis and differing in terms of molecular weight, electrophoretic mobility and biological activity were studied by polyacrylamide gel electrophoresis. A glycosylated form of prolactin with Mr 25 000 and possessing an increased biological activity towards pigeon crop was revealed. It was found that the carbohydrate component of this prolactin form is attached to asparagine at position 31; no differences were revealed between the amino acid composition of the major and glycosylated forms of the hormone. In the hypophysis, the glycosylated form content makes up to 30-40% of the total prolactin monomer content. A disulfide dimeric form of prolactin with Mr of about 50 000 was isolated and characterized.
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